Selected Publications – Nanomedicine

Mirkin, C. A.; Letsinger, R. L.; Mucic, R. C; Storhoff, J. J. “A DNA-based method for rationally assembling nanoparticles into macroscopic materials,” Nature, 1996, 382, 607-609, doi: 10.1038/382607a0.

Taton, T. A.; Mirkin, C. A.; Letsinger, R. L. “Scanometric DNA Array Detection with Nanoparticle Probes,” Science, 2000, 289, 1757-1760, doi: 10.1126/science.289.5485.1757.

Nam, J.-M.; Thaxton, C. S.; Mirkin, C. A. “Nanoparticle-Based Bio-Bar Codes for the Ultrasensitive Detection of Proteins,” Science, 2003, 301, 1884-1886, doi: 10.1126/science.1088755.

Georganopoulou, D. G.; Chang, L.; Nam, J.-M.; Thaxton, C. S.; Mufson, E. J.; Klein, W. L.; Mirkin, C. A. “Nanoparticle-Based Detection in Cerebral Spinal Fluid of a Soluble Pathogenic Biomarker for Alzheimer’s Disease,” Proc. Natl. Acad. Sci. USA, 2005, 102, 2273-2276, doi: 10.1073/pnas.0409336102.

Rosi, N. L.; Giljohann, D. A.; Thaxton, C. S.; Lytton-Jean, A.; Han, M. S.; Mirkin, C. A. “Oligonucleotide-Modified Gold Nanoparticles for Intracellular Gene Regulation,” Science, 2006, 312, 1027-1030, doi 10.1126/science.1125559.

Seferos, D. S.; Giljohann, D. A.; Hill, H. D.; Prigodich, A. E.; Mirkin, C. A. “Nano-flares: Probes for Transfection and mRNA Detection in Living Cells,” J. Am. Chem. Soc., 2007, 129, 15477-15479, doi: 10.1021/ja0776529.

Seferos, D. S.; Prigodich, A. E.; Giljohann, D. A.; Patel, P. C.; Mirkin, C. A. “Polyvalent DNA Nanoparticle Conjugates Stabilize Nucleic Acids,” Nano Lett., 2008, 9, 308-311, doi: 10.1021/nl802958f.

Giljohann, D. A.; Seferos, D. S.; Prigodich, A. E.; Patel, P. C.; Mirkin, C. A. “Gene Regulation with Polyvalent siRNA-Nanoparticle Conjugates,” J. Am. Chem. Soc., 2009, 131, 2072-2073, doi: 10.1021/ja808719p.

Massich, M. D.; Giljohann, D. A.; Seferos, D. S.; Ludlow, L. E.; Horvath, C. M.; Mirkin, C. A. “Regulating Immune Response Using Polyvalent Nucleic Acid – Gold Nanoparticle Conjugates,” Mol. Pharmaceutics, 2009, 6, 1934-1940, doi: 10.1021/mp900172m.

Cutler, J. I.; Auyeung, E; Mirkin, C. A.  “Spherical Nucleic Acids,” J. Am. Chem. Soc., 2012, 134, 1376-1391, doi 10.1021/ja209351u.

Choi, C. H. J.; Hao, L.; Narayan, S. P.; Auyeung, E.; Mirkin, C. A. “Mechanism for the Endocytosis of Spherical Nucleic Acid Nanoparticle Conjugates,” Proc. Natl. Aca. Sci. USA, 2013, 110, 7625-7630, doi 10.1073/pnas.1305804110.

Jensen, S. A.; Day, E. S.; Ko, C. H.; Hurley, L. A.; Luciano, J. P.; Kouri, F. M.; Merkel, T. J.; Luthi, A. J.; Patel, P. C.; Cutler, J. I.; Daniel, W. L.; Scott, A. W.; Rotz, M. W.; Meade, T. J.; Giljohann, D. A.; Mirkin, C. A.; Stegh, A. H. “Spherical Nucleic Acid Nanoparticle Conjugates as an RNAi-Based Therapy for Glioblastoma,” Science Trans. Med., 2013, 5, 209ra152, doi: 10.1126/scitranslmed.3006839.

Halo, T. L.; McMahon, K. M.; Angeloni, N. L.; Xu, Y.; Wang, W.; Chinen, A. B.; Malin, D.; Strekalova, E.; Cryns, V. L.; Cheng, C.; Mirkin, C. A.; Thaxton, C. S. “NanoFlares for the Detection, Isolation, and Culture of Live Tumor Cells from Human Blood,” Proc. Natl. Aca. Sci. USA, 2014, 111, 17104-17109, doi 10.1073/pnas.1418637111.

Banga, R. J.; Chernyak, N.; Narayan, S. P.; Nguyen, S. T.; Mirkin, C. A. “Liposomal Spherical Nucleic Acids,” J. Am. Chem. Soc., 2014, 136, 9866-9869, doi: 10.1021/ja504845f.

Brodin, J. D.; Sprangers, A. J.; McMillan, J.; Mirkin, C. A. “DNA-Mediated Cellular Delivery of Functional Enzymes,” J. Am. Chem. Soc., 2015, 137, 14838-14841, doi: 10.1021/jacs.5b09711.

Radovic-Moreno, A. F.; Chernyak, N.; Mader, C. C.; Nallagatla, S.; Kang, R.; Hao, L.; Walker, D. A.; Halo, T. L.; Merkel, T. J.; Rische, C.; Ananatatmula, S.; Burkhart, M.; Mirkin, C. A.; Gryaznov, S. M. “Immunomodulatory Spherical Nucleic Acids,” Proc. Natl. Aca. Sci. USA, 2015, 112, 3892-3897, doi: 10.1073/pnas.1502850112.

Alhasan, A. H.; Scott, A. W.; Wu, J. J.; Feng, G.; Meeks, J. J.; Thaxton, C. S.; Mirkin, C. A. “Circulating MicroRNA Signature for the Diagnosis of Very High-Risk Prostate Cancer,” Proc. Natl. Acad. Sci. USA, 2016, 113, 10655-10660, doi: 10.1073/pnas.1611596113.

Sita, T. L.; Kouri, F. M.; Hurley, L. A.; Merkel, T. J.; Chalastanis, A.; May, J. L.; Ghelfi, S. T.; Cole, L. E.; Cayton, T. C.; Barnaby, S. N.; Sprangers, A. J.; Savalia, N.; James, C. D.; Lee, A.; Mirkin, C. A.; Stegh, A. H. “Dual bioluminescence and near-infrared fluorescence monitoring to evaluate Spherical Nucleic Acid nanoconjugate activity in vivo,” Proc. Natl. Aca. Sci. USA, 2017, 114, 4129-4134, doi: 10.1073/pnas.1702736114.

Yamankurt, G.; Berns, E. J.; Xue, A.; Lee, A.; Bagheri, N.; Mrksich, M.; Mirkin, C. A. “Exploration of the Nanomedicine-design Space with High-Throughput Screening and Machine Learning,” Nature Biomedical Engineering, 2019, 3, 318-327, doi: 10.1038/s41551-019-0351-1.

Wang, Shuya; Qin, L.; Yamankurt, G.; Skakuj, K.; Huang, Z.; Chen, P.-C.; Dominquez, D.; Lee, A.; Zhang, B.; Mirkin, C. A. “Rational Vaccinology with Spherical Nucleic Acids,” Proc. Natl. Aca. Sci. USA, 2019, 116, 10473-10481, doi: 10.1073/pnas.1902805116.

Callmann, C. E.; Cole, L. E.; Kusmierz, C. D.; Huang, Z.; Horiuchi, D.; Mirkin, C. A. “Tumor Cell Lysate-Loaded Immunostimulatory Spherical Nucleic Acids as Therapeutics for Triple Negative Breast Cancer,” Proc. Natl. Aca. Sci. USA, 2020, 117, 17543-17550, doi: 10.1073/pnas.2005794117.

Samanta, D.; Ebrahimi, S. B.; Kusmierz, C. D.; Cheng, H. F.; Mirkin C. A. “Protein Spherical Nucleic Acids for Live-Cell Chemical Analysis,” J. Am. Chem. Soc., 2020, 142, 13350-13355, doi: 10.1021/jacs.0c06866.