Selected Publications – Nanomedicine

Mirkin, C. A.; Letsinger, R. L.; Mucic, R. C; Storhoff, J. J. “A DNA-based method for rationally assembling nanoparticles into macroscopic materials,” Nature, 1996, 382, 607-609, doi: 10.1038/382607a0.

Rosi, N. L.; Giljohann, D. A.; Thaxton, C. S.; Lytton-Jean, A.; Han, M. S.; Mirkin, C. A. “Oligonucleotide-Modified Gold Nanoparticles for Intracellular Gene Regulation,” Science, 2006, 312, 1027-1030, doi 10.1126/science.1125559.

Jensen, S. A.; Day, E. S.; Ko, C. H.; Hurley, L. A.; Luciano, J. P.; Kouri, F. M.; Merkel, T. J.; Luthi, A. J.; Patel, P. C.; Cutler, J. I.; Daniel, W. L.; Scott, A. W.; Rotz, M. W.; Meade, T. J.; Giljohann, D. A.; Mirkin, C. A.; Stegh, A. H. “Spherical Nucleic Acid Nanoparticle Conjugates as an RNAi-Based Therapy for Glioblastoma,” Science Trans. Med., 2013, 5, 209ra152, doi: 10.1126/scitranslmed.3006839.

Banga, R. J.; Chernyak, N.; Narayan, S. P.; Nguyen, S. T.; Mirkin, C. A. “Liposomal Spherical Nucleic Acids,” J. Am. Chem. Soc., 2014, 136, 9866-9869, doi: 10.1021/ja504845f.

Radovic-Moreno, A. F.; Chernyak, N.; Mader, C. C.; Nallagatla, S.; Kang, R.; Hao, L.; Walker, D. A.; Halo, T. L.; Merkel, T. J.; Rische, C.; Ananatatmula, S.; Burkhart, M.; Mirkin, C. A.; Gryaznov, S. M. “Immunomodulatory Spherical Nucleic Acids,” Proc. Natl. Aca. Sci. USA, 2015, 112, 3892-3897, doi: 10.1073/pnas.1502850112.

Yamankurt, G.; Berns, E. J.; Xue, A.; Lee, A.; Bagheri, N.; Mrksich, M.; Mirkin, C. A. “Exploration of the Nanomedicine-design Space with High-Throughput Screening and Machine Learning,” Nature Biomedical Engineering, 2019, 3, 318-327, doi: 10.1038/s41551-019-0351-1.

Wang, Shuya; Qin, L.; Yamankurt, G.; Skakuj, K.; Huang, Z.; Chen, P.-C.; Dominquez, D.; Lee, A.; Zhang, B.; Mirkin, C. A. “Rational Vaccinology with Spherical Nucleic Acids,” Proc. Natl. Aca. Sci. USA, 2019, 116, 10473-10481, doi: 10.1073/pnas.1902805116.

Callmann, C. E.; Cole, L. E.; Kusmierz, C. D.; Huang, Z.; Horiuchi, D.; Mirkin, C. A. “Tumor Cell Lysate-Loaded Immunostimulatory Spherical Nucleic Acids as Therapeutics for Triple Negative Breast Cancer,” Proc. Natl. Aca. Sci. USA, 2020, 117, 17543-17550, doi: 10.1073/pnas.2005794117.

Samanta, D.; Ebrahimi, S. B.; Kusmierz, C. D.; Cheng, H. F.; Mirkin C. A. “Protein Spherical Nucleic Acids for Live-Cell Chemical Analysis,” J. Am. Chem. Soc., 2020, 142, 13350-13355, doi: 10.1021/jacs.0c06866.

Teplensky M.H,; Distler M.E.; Kusmierz C.D.; Evangelopoulos M; Gula H.; Elli D; Tomatsidou A.; Nicolaescu V.; Gelarden I.; Yeldandi A.; Batlle D.; Missiakas D.; Mirkin C.A. “Spherical nucleic acids as infectious disease vaccine platform” Proc. Natl. Aca. Sci. USA, 2022, 199, e2119093119. doi: 10.1073/pnas.2119093119

Teplensky M.H.; Evangelopoulos M.; Dittmar J.W.; Forsyth C.M.; Sinegra A.J.; Wang S.; Mirkin C.A.”Multi antigen spherical nucleic acid cancer vaccines,” Nature Biomedical Engineering, 2023, 7, 911-927, doi: 10.1038/s41551-022-01000-2

Dittmar J.W.; Teplensky M.H. Evangelopoulos M; Qin L.; Zhang B.; Mirkin C.A. “Tuning DNA dissociation from spherical nucleic acids for enhanced immunostimulation’ ACS Nano, 2023 , 17, 17996- 18007, doi: 10.1021/acsnano.3c04333

Paranandi K.S.; Lee A. Stanik, N, Mirkin, C.A. ” Cellular export fate of liposomal spherical nucleic acids” ACS Nano, 2023 , 17, 19000-19010, doi/10.1021/acsnano.3c04608

Park J.; Evangelopoulos M.; Vasher M.K.; Kudruk S., Ramani N., Mayer V.; Solivan A.C.; Lee A.; Mirkin C.A.”Enhancing endosomal escape and gene regulation activity for spherical nucleic acids” Small, 2023 6:e2306902. doi: 10.1002/smll.202306902