Selected Publications – Spherical Nucleic Acids

Cutler, J. I.; Auyeung, E; Mirkin, C. A.  “Spherical Nucleic Acids,”  J. Am. Chem. Soc.2012134, 1376-1391, doi 10.1021/ja209351u.

Cutler, J. I.; Zhang, K.; Zheng, D.; Auyeung, E.; Prigodich, A. E.; Mirkin, C. A. “Polyvalent Nucleic Acid Nanostructures, ” J. Am. Chem. Soc., 2011, 133, 9254–9257, doi 10.1021/ja203375n.

Rosi, N. L.; Giljohann, D. A.; Thaxton, C. S.; Lytton-Jean, A.; Han, M. S.; Mirkin, C. A. “Oligonucleotide-Modified Gold Nanoparticles for Intracellular Gene Regulation,” Science2006312, 1027-1030, doi 10.1126/science.1125559.

Banga, R. J.; Chernyak, N.; Narayan, S. P.; Nguyen, S. T.; Mirkin, C. A. “Liposomal Spherical Nucleic Acids,” J. Am. Chem. Soc., 2014, 136, 9866-9869, doi: 10.1021/ja504845f, PMCID: PMC4280063, PMCID: PMC4280063.

Brodin, J. D.; Sprangers, A. J.; McMillan, J.; Mirkin, C. A. “DNA-Mediated Cellular Delivery of Functional Enzymes,” JACS, 2015, 137, 14838-14841, doi: 10.1021/jacs.5b09711.

Calabrese, C. M.; Merkel, T. J.; Briley, W. E.; Randeria, P. S.; Narayan, S. P.; Rouge, J. L.; Walker, D. A.; Scott, A. W.; Mirkin, C. A. “Biocompatible Infinite-Coordination-Polymer Nanoparticle-Nucleic Acid Conjugates for Antisense Gene Regulation,” Angew Chem., 2014, 54, 476-480, doi: 10.1002/anie.201407946, PMCID: PMC4314394.

Cutler, J. I.; Zheng, D.; Xu, X.; Giljohann, D. A.; Mirkin, C. A. “Polyvalent Oligonucleotide Iron Oxide Nanoparticle “Click” Conjugates,” Nano Lett., 2010, 10, 1477–1480, doi: 10.1021/nl100477m, PMCID: PMC2874426.

Morris, W.; Briley, W.E.; Auyeung, E.; Cabezas, M.D.; Mirkin, C.A.; “Nucleic Acid-Metal Organic Framework (MOF) Nanoparticle Conjugates,” J. Am. Chem. Soc., 2014, 136, 7261-7264, doi: 10.1021/ja503215w.

Young, K. L; Scott, A. W.; Hao, L.; Mirkin, S. E.; Liu, G.; Mirkin, C. A. “Hollow Spherical Nucleic Acids for Intracellular Gene Regulation Based Upon Biocompatible Silica Shells,” Nano Lett., 2012, 12, 3867–3871, doi: 10.1021/nl3020846, PMCID: PMC3397824.

Seeman, N. C. “An Overview of Structural DNA Nanotechnology,” Mol. Biotechnol.200737, 246-257, doi 10.1007/s12033-007-0059-4.

Seferos, D. S.; Giljohann, D. A.; Hill, H. D.; Prigodich, A. E.; Mirkin, C. A. “Nano-flares: Probes for Transfection and mRNA Detection in Living Cells,” J. Am. Chem. Soc., 2007, 129, 15477-15479, doi: 10.1021/ja0776529, PMCID: PMC3200543.

Zheng, D.; Seferos, D. S.; Giljohann, D. A.; Patel, P. C.; Mirkin, C. A, “Aptamer Nano-Flares for Molecular Detection in Living Cells,” Nano Lett., 2009, 9, 3258-3261, doi: 10.1021/nl901517b, PMCID: PMC3200529.

Choi, C. H. J.; Hao, L.; Narayan, S. P.; Auyeung, E.; Mirkin, C. A. “Mechanism for the Endocytosis of Spherical Nucleic Acid Nanoparticle Conjugates,” Proc. Natl. Aca. Sci.2013110, 7625-7630, doi 10.1073/pnas.1305804110.

Prigodich, A. E.; Randeria, P. S.; Briley, W.; Kim, N.; Daniel, W. L.; Giljohann, D. A.; Mirkin, C. A. “Multiplexed Nanoflares: mRNA Detection in Live Cells,” Anal. Chem., 2012, 84, 2062-2066, doi: 10.1021/ac202648w, PMCID: PMC3357311.

Halo, T. L.; McMahon, K. M.; Angeloni, N. L.; Xu, Y.; Wang, W.; Chinen, A. B.; Malin, D.; Strekalova, E.; Cryns, V. L.; Cheng, C.; Mirkin, C. A.; Thaxton, C. S. “NanoFlares for the Detection, Isolation, and Culture of Live Tumor Cells from Human Blood,” Proc. Natl. Aca.Sci.2014111, 17104-17109, doi 10.1073/pnas.1418637111.

Taton, T. A.; Mirkin, C. A.; Letsinger, R. L. “Scanometric DNA Array Detection with Nanoparticle Probes,” Science, 2000, 289, 1757-1760, doi: 10.1126/science.289.5485.1757.

Hill, H. D.; Mirkin, C. A. “The Bio-Barcode Assay for the Detection of Protein and Nucleic Acid Targets Utilizing Dithiothreitol Induced Ligand Exchange,” Nature Protocols, 2006, 1, 324-336, doi: 10.1038/nprot.2006.51.

Nam, J.-M.; Thaxton, C. S.; Mirkin, C. A. “Nanoparticle-Based Bio-Bar Codes for the Ultrasensitive Detection of Proteins,” Science, 2003, 301, 1884-1886, doi: 10.1126/science.1088755.

Georganopoulou, D. G.; Chang, L.; Nam, J.-M.; Thaxton, C. S.; Mufson, E. J.; Klein, W. L.; Mirkin, C. A. “Nanoparticle-Based Detection in Cerebral Spinal Fluid of a Soluble Pathogenic Biomarker for Alzheimer’s Disease,” Proc. Natl. Acad. Sci., 2005, 102, 2273-2276, doi: 10.1073/pnas.0409336102, PMCID: PMC548981.

Alhasan, A. H.; Kim, D. Y.; Daniel, W. L.; Watson, E.; Meeks, J. J.; Thaxton, C. S.; Mirkin, C. A. “Scanometric microRNA (Scano-miR) Array Profiling of Prostate Cancer Markers Using Spherical Nucleic Acid (SNA)-Gold Nanoparticle Conjugates,” Anal. Chem., 2012, 84, 4153-4160, doi: 10.1021/ac3004055, PMCID; PMC3357313.

Kim, D.; Daniel, W. L.; Mirkin, C. A. “A Microarray-based Multiplexed Scanometric Immunoassay for Protein Cancer Markers Using Gold Nanoparticle Probes,” Anal. Chem., 2009, 81, 9183-9187, doi: 10.1021/ac9018389, PMCID: PMC3200545.

Lytton-Jean, A. K. R.; Mirkin, C. A. “A Thermodynamic Investigation into the Binding Properties of DNA Functionalized Gold Nanoparticle Probes and Molecular Fluorophore Probes,” J. Am. Chem. Soc.,2005127, 12754-12755, doi 10.1021/ja052255o.

Seferos, D. S.; Prigodich, A. E.; Giljohann, D. A.; Patel, P. C.; Mirkin, C. A. “Polyvalent DNA Nanoparticle Conjugates Stabilize Nucleic Acids,” Nano Lett., 2008, 9, 308-311, doi: 10.1021/nl802958f, PMCID: PMC3918421.

Massich, M. D.; Giljohann, D. A.; Seferos, D. S.; Ludlow, L. E.; Horvath, C. M.; Mirkin, C. A. “Regulating Immune Response Using Polyvalent Nucleic Acid – Gold Nanoparticle Conjugates,” Mol. Pharmaceutics, 2009, 6, 1934-1940, doi: 10.1021/mp900172m, PMCID: PMC3241524.

Giljohann, D. A.; Seferos, D. S.; Patel, P. C.; Millstone, J. E.; Rosi, N. L.; Mirkin, C. A. “Oligonucleotide Loading Determines Cellular Uptake of DNA-Modified Gold Nanoparticles, Nano Lett., 2007, 7, 3818-3821, doi: 10.1021/nl072471q.

Giljohann, D. A.; Seferos, D. S.; Prigodich, A. E.; Patel, P. C.; Mirkin, C. A. “Gene Regulation with Polyvalent siRNA-Nanoparticle Conjugates,” J. Am. Chem. Soc., 2009, 131, 2072-2073, doi: 10.1021/ja808719p, PMCID: PMC2843496.

Jensen, S. A.; Day, E. S.; Ko, C. H.; Hurley, L. A.; Luciano, J. P.; Kouri, F. M.; Merkel, T. J.; Luthi, A. J.; Patel, P. C.; Cutler, J. I.; Daniel, W. L.; Scott, A. W.; Rotz, M. W.; Meade, T. J.; Giljohann, D. A.; Mirkin, C. A.; Stegh, A. H. “Spherical Nucleic Acid Nanoparticle Conjugates as an RNAi-Based Therapy for Glioblastoma,” Science Trans. Med., 2013, 5, 209ra152, doi: 10.1126/scitranslmed.3006839, PMCID: PMC4017940.

Randeria, P. S.; Seeger, M. A.; Wang, X. Q.; Wilson, H.; Shipp, D.; Mirkin, C. A.; Paller, A. S. “siRNA-based Spherical Nucleic Acids Reverse Impaired Wound Healing in Diabetic Mice by GM3 Synthase Knockdown,” PNAS, 2015, 112, 5573-5578, doi: 10.1073/pnas.1505951112, PMCID: PMC4426446.

Radovic-Moreno, A. F.; Chernyak, N.; Mader, C. C.; Nallagatla, S.; Kang, R.; Hao, L.; Walker, D. A.; Halo, T. L.; Merkel, T. J.; Rische, C.; Ananatatmula, S.; Burkhart, M.; Mirkin, C. A.; Gryaznov, S. M. “Immunomodulatory Spherical Nucleic Acids,” Proc. Natl. Aca. Sci, 2015, 112, 3892-3897, doi: 10.1073/pnas.1502850112, PMCID: PMC4386353.

Jacobson, R.; Zhang, X.; DuBose, R.; Matthews, B. Nature 1994, 369, 761.